mucosal immunity

The mucosa – associated lymphoid tissue or (MALT)
Dr.Baha, Hamdi AL-Amiedi
Local immune component are recently being ?? talked by immunologist as an active local immune system it consist of both B- and T- Cells epithelial cell producing secretory piece they can fix up both humoral and cellular immune response in site , the mucosa – associated lymphoid tissue or (MALT) the main mucosa- associated lymphoid tissue are the gastrointestinal tract ( including oral mucosa and salivery gland , the genitourinary tract , the respiratory tract and the secretion of the mammary glands
local immune stimulated ?? mucosa- associated lymphoid tissue which is organized into discrete areas in the gut known as Peyer patches just below the epithelial cells in the lamina propria Antigen travels through specialized epithelium(M Cells) to the subepithelial lymphoid tissue.The main antibody produced at these sites is secretory oral cavity : the oral cavity? environment is controlled primary by saliva mucosal surface saliva contain several non- specific host factores (mucins,lactoferrin,lysozyme, peroxidase, Histatins, cystains, salivery glycoprotein)
It is well established that S.IgA is predominant ? immunoglobulin in whole saliva it is considered to be the main specific defense mechanism in oral surface by limiting
microbial adherence to epithelial & tooth ? surface by neutralizing toxin& host factors , dimeric immunoglobulin which aquires it secretory component during transport across the
There are several factors which may prevent penetration intact of oral mucosa by microorganisms:
1-saliva
2-keratin
3-granular-layer
4-basment membrane
5-leucocytes
6-antibody